St. John’s Wort Extract Hypericin

Botanical Name:Hypericum perforatum
Part Used:Whole herb
Active ingredients:Hypericin
Appearance: Dark Brown Powder
Specification:0.3% by HPLC
Storage: Stored in a cool, dry and dark place, shelf life 24 months.

What is St. John’s Wort Extract Hypericin?

St. John’s Wort has become extremely popular in recent decades as a potential cure-all herbal remedy for a wide swath of conditions. Unlike many other herbal treatments, many of the health benefits of have been verified by the scientific community, and the herbal supplements are commonly prescribed by medical professionals. St. John’s Wort is a small flowering plant from the Hypericum genus that has the scientific name of Hypericum perforatum, and it grows wild in Europe, but has since spread to the Americas, Russia, Asia, China, and the Middle East. You might know St. John’s Wort by a different name, such as rosin rose or goatweed, but they all have the same impact! The vast range of its health effects make St. John’s Wort such an important factor in herbal supplementation, and it is now widely available throughout the world.

Health Benefits of St. John’s Wort Extract Hypericin

Anti-Depressant Qualities: Perhaps the most well-known effect of St. John’s Wort Extract is its anti-depressant nature. It has been widely used to relieve symptoms of depression for generations, and is now a popular natural solution that doctors and psychiatrists often prescribe to their patients. It contains a rare combination of antidepressant chemicals that inhibit or delay the reuptake of certain neurotransmitters like serotonin, dopamine, and norepinephrine, thereby giving out bodies additional energy and pleasure, chasing away depressive symptoms.

Other Mental Effects: This quality extends past depression, despite that being the most publicized benefit, to help people sufferingfrom anxiety and mood swings as well. By helping to regulate the hormonal balance in the body, St. John’s Wort is able to get the metabolism and internal clock back in line, providing help for sleeplessness, irritability, and chronic fatigue. Eliminating chronic stresshormones from the body can also improve overall health and cognitive function, as excess stress hormones can permanently alter various organ systems.

Menopausal Mood Swings: There are two distinct periods in feminine sexual health that can be challenging in terms of mood swings; pre-menstrual syndrome and menopause. St. John’s Wort is widely recommended for women in both of these periods of their life, as the chemical constituents have been shown to reduce mood swings and anxiety in menopausal women, and also reduce the severity of cramping and pre-menstrual irritation and depression.

Addiction and Withdrawal: Although additional research on this particular benefit is still ongoing, early indications show that the use of St. John’s Wort can be very helpful in easing cravings and withdrawal symptoms after quitting cigarettes, alcohol, or other addictive substances. This could prove very useful, as addiction and recovery is a challenging and flawed science at present.

Antiviral Agent: New research has recently come to light that St. John’s Wort has certain antiviral capabilities, including the prevention or reduction of risk for AIDS, hepatitis, and other serious viral conditions. The only problem with this is that very high doses of it are required for this sort of antiviral effect, which would also cause a range of unpleasant side effects. Additional research into finding a happy balance in this specialized area of health is ongoing.

Hormonal Balance: As already expressed in the explanation of the antidepressant effects of St. John’s Wort, the active ingredients have strong effects on hormone regulation in the body. Hypothyroidism is one of the most common thyroid disorders and it has been shown to reduce those symptoms and help the thyroid gland produce normal levels of hormones again.

Anti-Inflammatory Agent: The soothing nature of St. John’s Wort extract and the rich concentration of antioxidant and anti-inflammatorycompounds make it perfect for easing the aching pains of arthritis, in addition to gout, joint discomfort, and muscle aches. Just as it helps ease inflammation on the skin and in the gut, St. John’s Wort extract also lowers inflammation in the cardiovascular system, thereby helping to lower blood pressure and decrease stress on the heart.

Skin Treatment: If you use St. John’s Wort extract in topical application in the form of a salve or tincture, it can speed the healing process of burns, bruises, and scrape by stimulating circulation of oxygenated blood to those skin cells so that repairs can begin.

Pregnancy Pains: While pregnant, hemorrhoids or other stretched out areas of the body can become very painful. Although it is not recommended to take oral supplements throughout the pregnancy, topical application of St. John’s Wort salves and pastes are highly recommended for women suffering from these pregnancy-related conditions.

Anti-Cancer Effects: Cancer research has recently begun putting more faith in the role that St. John’s Wort could play. Laboratory research has shown a definite correlation between the prevention and treatment of leukemia with consistent use of St. John’s Wort extract supplements. Any cancer-preventing substance is highly valued, and this research will certainly be ongoing.

Dosage of St. John’s Wort Extract Hypericin



  • For mild to moderate depression:
    • In most studies, St. John’s wort extract was standardized to 0.3% hypericin content and used at doses of 300 mg three times daily.
    • Some studies have used St. John’s wort extract standardized to 0.2% hypericin at doses of 250 mg twice daily.
    • St. John’s wort extract standardized to 5% hyperforin has been used at doses of 300 mg three times daily.
  • For premenstrual syndrome (PMS): St. John’s wort extract standardized to 0.3% hypericin dosed at 300 mg once daily has been used.
  • For body symptoms associated with depression: 300 mg three times daily of the standardized hypericin extract has been used.
  • For somatization disorder: a specific extract (LI 160, Lichtwer Pharma) 600 mg/day has been used.


  • For wound healing: An ointment containing a 5% St. John’s wort extract applied three times daily beginning 24 hours after a C-section and continued for 16 days has been used.



  • For mild to moderate depression: 150-300 mg of St. John’s wort three times daily for 8 weeks in children 6-17 years-old has been used. A specific St. John’s wort extract (LI 160, Lichtwer, Pharma) 300-1800 mg in three divided doses daily for up to 6 weeks has been used.

Do not suddenly stop taking St. John’s wort. This might cause unpleasant side effects. If you decide to stop taking St. John’s wort, reduce the dose slowly over time.

Potential Side Effects of St. John’s Wort Extract Hypericin

St. John’s wort is LIKELY SAFE when taken by mouth for up to 12 weeks. Some evidence suggests it can be used safely for over one year. It can cause some side effects such as trouble sleeping, vivid dreams, restlessness, anxiety, irritability, stomach upset, fatigue, dry mouth, dizziness, headache, skin rash, diarrhea, and tingling. Take St. John’s wort extract in the morning or lower the dose if it seems to be causing sleep problems.

St. John’s wort is POSSIBLY UNSAFE when taken by mouth in large doses. When taken by mouth in large doses, it might cause severe reactions to sun exposure. Wear sun block outside, especially if you are light-skinned.

St. John’s wort interacts with many drugs (see the section below). Let your healthcare provider know if you want to take St. John’s wort extract. Your healthcare provider will want to review your medications to see if there could be any problems.

There isn’t enough reliable information available to know if St. John’s wort is safe when it is applied to the skin. St. John’s wort might cause severe reactions to sun exposure.

Certificate of Analysis

AssayHypericin 0.3%HPLCComplies
AppearenceDark brown powderN/AComplies
Particle size100% pass 80 meshUSP32<786>Complies
Extract SolventsWater/EthanolN/AComplies
IdentificationPositive ReactionN/AComplies
Loss on Drying≤5.0%Eur.Ph.6.0[2.8.17]Complies
Acid-insoluble ash≤7.0%Eur.Ph.6.0[2.4.16]Complies
Solvents ResidueMeet Eur.Ph6.0<5.4>Eur.Ph 6.0<2.4.24>Complies
Pesticides ResidueNegativeUSP32<561>Complies
Microbiological Control
Total bacterial count≤1000cfu/gUSP30<61>Complies
Yeast & mold≤100cfu/gUSP30<61>Complies

Flowchart of Production

plant extract flowchart

Package for St. John’s Wort Extract Powder Hypericin

herbal extract package

Shipping for St. John’s Wort Extract Powder Hypericin

  • By Express: Suitable for under 50kg, 5-10 days
  • By Air: Suitable for more than 50kg, 7-15 days
  • By Sea: Suitable for more than 500kg, 15-45days

Why Choose FYZ St. John’s Wort Extract Hypericin?

  • FYZ is a professional GMP standard herbal extract manufacturer in China, provide OEM service.
  • FREE SAMPLE with freight collection (5-10g) for detection, if you need more, please contact us.
  • Fast delivery by DHL/FedEx,  air as your requirement.
  • All of our products from nature, no additive.
  • Money refund policy.



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