Peanut Shell Extract Luteolin

Botanical Name:Arachis hypogaea
Part Used:Shell
Active ingredients:Luteolin
Appearance:Yellowish green powder
Specification:98% by HPLC
Storage: Stored in a cool, dry and dark place, shelf life 24 months.

What is Peanut Shell Extract Luteolin?

Luteolin is a common flavonoid. Its sources include many varieties of plants including fruits, vegetables, and medicinal herbs. Plants sources rich in luteolin have appeared in Chinese traditional medicine for treating many diseases such as hypertension, inflammatory disorders, and cancer. Luteolin may even help to reduce niacin-induced flush.

Luteolin is considered by some to be a supper nutrient as it helps reduce inflammation, and promotes nerve and muscle function. It is found in artichoke leaves, parsley, celery, peppers, olive oil, rosemary, lemons, sage, peppermint, thyme and other foods. Basic research results indicate luteolin as an anti-inflammatory agent with other potential effects on septic shock.

Luteolin is a natural anti-oxidant with not as much pro-oxidant (inducing oxidative stress) potential than the most studied flavonoid quercetin, but apparently with a better safety profile.
It exhibits outstanding radical scavenging and cytoprotective properties, especially when tried in complex biological systems where it can interact with other anti-oxidants like vitamins. It has been suggested for multiple sclerosis on the basis of in vitro work.

Health Benefits of Peanut Shell Extract Luteolin

1) Luteolin Fights Cancer
Luteolin interferes with nearly all types of cancer cells.

It inhibits the growth of new blood vessels in tumors, the metabolism of carcinogens, as well as stopping the progression of the cell cycle in cancer cells. Luteolin also induces cell death in cancer cells.

In mice, luteolin suppressed growth of tumors formed from human skin carcinoma, hepatoma, and human ovarian cancer cells.

Luteolin inhibited the incidence rate of tumors and decreased the size of tumors significantly.

Long term treatment did not show any apparent toxicity in rats at a dose of 30mg/kg, implying that luteolin is relatively safe as an anticancer agent.

Through in vitro and vivo experiments, luteolin was found to have therapeutic and preventative activities against cancer associated with estrogen.

2) Luteolin Decreases Inflammation
Experiments with animals show that luteolin suppresses bacteria-induced inflammation.

Luteolin is also found to suppress two major pathways involved in response to inflammation, which greatly reduces both acute and chronic inflammation.

Luteolin suppressed pro-inflammatory marker expression and cytokine expression in LPS-activated microglia.

In an experiment on rats with toxin-induced uveitis, luteolin had great success in anti-inflammatory treatment, comparable to that of prednisolone.

Luteolin can also inhibit colitis (inflammation in the colon).

3) Luteolin is an Antioxidant
Luteolin is an oxygen scavenger. It was found to inhibit reactive oxygen species, which induce damage of lipids, DNA, and protein.

Luteolin significantly induces genes related to antioxidant defense.

4) Luteolin is a Natural Sun Protectant
Luteolin potently inhibited UVB-induced MMP-1 expression and wrinkle formation in vitro and in vivo and therefore may be used for prevention of UVB-induced skin aging.

5) Luteolin Improves Heart Function
In an experiment on rats, luteolin was found to inhibit cell death in the cells of the heart. This suggest that luteolin can be used in the prevention and treatment of cardiovascular diseases.

Luteolin substantially increased cell life while reducing evidence of oxidative stress-induced damage in the cells.

Luteolin also improved the recovery of heart cells contracting function following simulated injury caused by loss of blood flow, by reducing oxidative stress.

6) Luteolin Protects the Brain From Neurological Impairments
Luteolin treatment in rats reduced brain damage caused by kainic acid by reducing glutamate levels, mitigating inflammation, and enhancing the hippocampus.

Tests on flies expressing a neurological impairment that resembles amyloidosis showed that luteolin rescued the impairment.

Luteolin induces neurite outgrowth through CREB activation. CREB activation is the mechanism underlying its effects on memory enhancement.

Luteolin can go through the blood-brain-barrier (BBB), which shows anti-amnesic effects against the toxicity of amyloid in mice.

In an experiment on rats with streptozotocin induced Alzheimer’s disease, luteolin significantly improved spatial learning and memory impairment.

Luteolin also protects against high-fat diet-induced cognitive defects in obesity mice.

7) Luteolin is an Antiviral
Luteolin was found to have potent antiviral activity against Japanese encephalitis virus (JEV).

Luteolin reduced the number of Epstein-Barr virus reactivating cells and reduced the production of the virus. It does this by repressing the activities of the promoters of the immediate-early genes Zta and Rta.

In mice with hepatitis B virus (HBV), Luteolin reduced HBV DNA replication, suggesting that it may be used for anti-HBV therapy.

8) Luteolin Prevents Cataracts
In rats, luteolin enhanced the antioxidant potential and lowered the oxidative damage to the lens’ of rats in selenite-induced cataracts. It also improved the membrane integrity of the lens.

9) Luteolin May Be Therapeutic for Multiple Sclerosis
Multiple Sclerosis is a disease that affects the immune system – nerve damage causes pain and fatigue. Luteolin has anti-oxidant and anti-inflammatory effects which can reduce the effects of multiple sclerosis.

10) Luteolin Inhibits Mast Cells
Luteolin inhibits mast cells and mast cell-dependent T cell activation, factors which contribute to multiple sclerosis.

In this way, it can also help with histamine intolerance.

11) Luteolin Has Anti-Depressant Effects
The endoplasmic reticulum in a cell can undergo stress, which can cause cell death. In the brain, neuronal cells undergo cell death and this can cause symptoms of depression.

Luteolin significantly suppresses cell death by relieving endoplasmic reticulum stress.

Dosage of Peanut Shell Extract Luteolin

This natural substance is completely non-toxic. The ideal active dose for optimal efficacy has been defined as 100mg (80% luteolin) a day. Since its effects are maximised by other flavonoids, it should be taken with the main meals of the day.

Potential Side Effects of Peanut Shell Extract Luteolin

There has not been enough human studies with luteolin supplements to determine the idea dosage or the long term side effects.

Certificate of Analysis

AssayLuteolin 98%HPLCComplies
AppearenceYellowish green powderN/AComplies
Particle size100% pass 80 meshUSP32<786>Complies
Extract SolventsWater/EthanolN/AComplies
IdentificationPositive ReactionN/AComplies
Loss on Drying≤5.0%Eur.Ph.6.0[2.8.17]Complies
Acid-insoluble ash≤7.0%Eur.Ph.6.0[2.4.16]Complies
Solvents ResidueMeet Eur.Ph6.0<5.4>Eur.Ph 6.0<2.4.24>Complies
Pesticides ResidueNegativeUSP32<561>Complies
Microbiological Control
Total bacterial count≤1000cfu/gUSP30<61>Complies
Yeast & mold≤100cfu/gUSP30<61>Complies

Flowchart of Production

plant extract flowchart

Package for Peanut Shell Extract Luteolin

herbal extract package

Shipping for Peanut Shell Extract Luteolin

  • By Express: Suitable for under 50kg, 5-10 days
  • By Air: Suitable for more than 50kg, 7-15 days
  • By Sea: Suitable for more than 500kg, 15-45days

Why Choose FYZ Peanut Shell Extract Luteolin?

  • FYZ is a professional GMP standard herbal extract manufacturer in China, provide OEM service.
  • FREE SAMPLE with freight collection (5-10g) for detection, if you need more, please contact us.
  • Fast delivery by DHL/FedEx,  air as your requirement.
  • All of our products from nature, no additive.
  • Money refund policy.



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