What is Luo Han Guo Extract Mogroside V?
Luo han guo is a herbaceous perennial vine. It grows mainly in southern China and northern Thailand. The plant is valued mainly for its fruit which has also been known as the ‘longevity fruit’. The fruit has been used to cool drinks and in Chinese medicine. It is round and smooth and can be yellowish-brown or greenish brown in color. It contains a sweet, fleshy edible pulp. The fruit extract is used as a sweetener, since this is known to be almost 300 times sweeter as compared to sugar. It has been used for centuries by the Chinese as a low calorie sweetener to treat obesity and diabetes.
Luo han guo contains a group of compounds known as mogrosides. These compounds, along with glucose and fructose, are responsible for the intense sweetness of the fruit. They are estimated to be about 150 to 300 times sweeter than sucrose. This has made the luo han guo extract popular as a low calorie sweetener. In Japan, the purified compound, mogroside V, is approved as a high intensity sweetening agent. Studies have also suggested that luo han guo has an anti-hyperglycemic effect that could make it useful in regulating blood sugar levels of diabetics.
Health Benefits of Luo Han Guo Extract Mogroside V
Fruits of luo han guo are intensely sweet, with the purified constituents estimated to be about 150 times sweeter than sucrose. There is potential for use as a noncaloric sweetener. The purified, sweet principle, mogroside V, is approved as a high-intensity sweetening agent in Japan.
Highly sweet cucurbitane glycosides from the fruits of luo han guo, and other plant extracts, were evaluated for sweetness using electrophysiological and behavioral testing in gerbils. Gerbils trained to avoid sucrose identified the extracts as being sweet through avoidance. Another study in gerbils showed that mogroside V stimulated the gustatory receptors and induced behavioral responses to the compound’s sweet taste.
In addition to its natural sweetening characteristic, luo han guo has exhibited antihyperglycemic effects. In rats, crude extracts of S. grosvenori and the triterpene glycosides inhibited a rise in postprandial blood glucose levels when given orally 3 minutes prior to oral administration of maltose. The suggested antihyperglycemic effect was via the inhibition of maltase.
Luo han guo extract and the cucurbitane glycosides mogroside IV, mogroside V, 11-oxo-mogroside V, and siamenoside I inhibited copper-mediated, low-density, lipoprotein and cell-mediated, low-density lipoprotein oxidation in a dose-dependent fashion, with 11-oxo-mogroside V as the most active component.
The antioxidant, free-radical scavenging activities of the extract and 11-oxo-mogroside V were less than those of vitamin E in the same in vivo study.
In vitro and animal studies suggest potential cancer chemopreventive activities of cucurbitane glycosides and related compounds from the fruit of luo han guo.An ethanol extract of S. grosvenori was evaluated for its effect on Epstein-Barr virus-early antigen (EBV-EA) activation as a method of detecting chemoprotective activity. The extract inhibited activation of EBV-EA at a level similar to or greater than the activity of beta-carotene. In a similar study, 11-oxo-mogroside V and mogroside V showed strong inhibitory effects.
A 2-stage skin carcinogenesis model in mice ingesting mogroside V or 11-oxomogroside V showed delayed development and reduced numbers of papillomas at 10 and 15 weeks, respectively, compared with control group animals.
Inhibitory effects of mogroside V and 11-oxo-mogroside V on another skin carcinogenesis model in mice using peroxynitrite also showed a reduction in numbers of papillomas formed and delayed papilloma development.
The effect of luo han guo extract and its glycosides on allergic symptoms in mice were studied. No effect on skin scratching behavior or nasal rubbing was noted following single doses of 300 and 1,000 mg/kg, respectively, of the extract or the glycosides.
Repeated daily doses of 300 and 1,000 mg/kg/day between 2 and 4 weeks of luo han guo extract and the glycosides showed gradual inhibition of nasal rubbing and skin scratching.
Dosage of Luo Han Guo Extract Mogroside V
No trials have been conducted to establish appropriate dosage. One half to 2 pieces (approximately 9 to 15 g) of the dried fruit is commonly used as a tea by simmering in boiling water.
Potential Side Effects of Luo Han Guo Extract Mogroside V
There are no reported monk fruit side effects or negative reactions, which means it’s safe for adults, children and pregnant/nursing women. It was approved by the FDA in 2010 as generally safe for consumption, which is relatively recent. There are no long-term studies available to test monk fruit side effects over time, so it’s always best to exercise care when consuming
Certificate of Analysis
|Assay||Mogroside V 50%||HPLC||Complies|
|Particle size||100% pass 80 mesh||USP32<786>||Complies|
|Loss on Drying||≤5.0%||Eur.Ph.6.0[2.8.17]||Complies|
|Solvents Residue||Meet Eur.Ph6.0<5.4>||Eur.Ph 6.0<2.4.24>||Complies|
|Total bacterial count||≤1000cfu/g||USP30<61>||Complies|
|Yeast & mold||≤100cfu/g||USP30<61>||Complies|
Flowchart of Production
Package for Luo Han Guo Extract Mogroside V
Shipping for Luo Han Guo Extract Mogroside V
- By Express: Suitable for under 50kg, 5-10 days
- By Air: Suitable for more than 50kg, 7-15 days
- By Sea: Suitable for more than 500kg, 15-45days
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