What is Goji Berry Extract Polysaccharide?
Goji berry, also called the wolfberry, is a bright orange-red berry that comes from a shrub that’s native to China. In Asia, goji berries have been eaten for generations in the hope of living longer.
Over time, people have used goji berries to try to treat many common health problems like diabetes, high blood pressure, fever, and age-related eye problems. Goji berries are eaten raw, cooked, or dried (like raisins) and are used in herbal teas, juices, wines, and medicines.
Chemical Constituents of Goji Berry Extract
Major compounds isolated from the goji berry include the carotenoids beta-carotene, lutein, lycopene, zeaxanthin, zeaxanthin dipalmitate, polysaccharides (comprising 30% of the pulp), vitamins (ascorbic acid, glucopyranosyl ascorbic acid, tocopherol), fatty acids, betaine, and peptidoglycans.
Neutral volatile compounds identified include steroids, glycolipids (including the cerebrosides), glycosides, glucopyranosides, and alkaloids (spermine alkaloid, polyhydroxylated alkaloids). Flavonoids, phenolic amides, cyclic peptides, and sesquiterpenes have also been described. Additionally, rutin, chlorogenic acid, and lyciumosides have been identified in the leaf, and phenolic amides identified in the root bark.
The goji berry contain dietary amounts of calcium, potassium, iron, zinc, and selenium, as well as riboflavin and vitamin C. Concern has been raised about the amount of atropine present in berries; only trace amounts were found and at levels considered insignificant (up to a maximum of 19 ppb w/w).
Health Benefits of Goji Berry Extract
Potent superoxide anion scavenging activity has been demonstrated for the goji berry extract polysaccharide. Activity of polysaccharide extract 500 mg has been estimated to be greater than vitamin C 500 mg.
In older mice, the decreased activity of enzymes in the brain, liver, and heart consequent to oxidative stress was enhanced by administration of polysaccharides extracted from Lycium fruits, lending support to the traditional anti-aging use of Gou Qi Zi.
Goji berry extract has been used traditionally to treat infertility. In mice with heat- and time-damaged seminiferous tubules, the goji berry extract polysaccharide inhibited apoptosis and reversed morphological damage. Protection against DNA-induced seminiferous tubule damage was also demonstrated in mice, and these actions are attributed to anti-oxidative activity. Doxorubicin-induced cardiac oxidative stress was decreased in rats pretreated with the aqueous extract of L. barbarum , and anti-oxidative effects on human dermal fibroblasts have been demonstrated.
Healthy mice fed goji berry extract maintained normal blood glucose levels, while streptozocin- and alloxan-induced diabetic rats and rabbits showed decreases in blood glucose levels.
A hypolipidemic effect was also observed. Improved insulin resistance has been demonstrated in non-insulin dependent diabetic rats.
Pretreatment with an aqueous extract of the L. chinense fruits decreased hepatic enzyme levels (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) in rats with carbon tetrachloride-induced hepatic injury. Histological changes were also decreased. Similar results were obtained for zeaxanthin extract against induced hepatic fibrosis in rats. Lycium compounds with potential hepato-protective (possibly antioxidant) effects have been identified.
Experiments investigating the potential of goji berry in cancer treatment focus on immune-enhancing and direct effects. The weight of the thymus and spleen in rats was increased, as was macrophage activity, with administration of a polysaccharide extract. Increased cytotoxic T lymphocyte and tumor necrosis factor activity have occurred in animal experiments and in human mononuclear cells in vitro. Protection from the effects of myelosuppression has been reported.
Aqueous extracts inhibit proliferation and induce apoptosis in hepatocellular cancer in rats and human hepatoma cell lines. Growth of sarcoma in mice was suppressed while an observational study suggested a benefit for cancer patients taking goji berry extract polysaccharides.
Experiments investigating the effect of goji berry extract polysaccharides have found enhanced spontaneous electrical activity in the hippocampus, and a decreased stroke index and neurological score in ischemia and reperfusion models. Neuronal death and apoptosis have been prevented, in animal experiments. In rats, beta-amyloid peptide neurotoxicity has been prevented, suggesting a role for the berry in Alzheimer disease.
Inhibition of monoamine oxidase B, which is elevated in neurodegenerative disease and aging, has been demonstrated with Lycium .
Effects on the eye are thought to be related to antioxidant activity. The berries are rich in zeaxanthin and increased plasma zeaxanthin levels have been demonstrated with berry consumption. Lutein content in the berries is somewhat lower. Fifteen grams of berries per day for 28 days increased total and lipid-standardized plasma zeaxanthin levels. Bioavailability of zeaxanthin is variable and experiments have been conducted to increase the availability using milk-based and emulsion formulations.
Increased survival of retinal ganglion cells has been demonstrated in experiments in rats with induced glaucoma. No effect on ocular pressure was found. The effect did not appear to be dose-dependent, and a prolonged effect (4 weeks) was demonstrated.
Antifungal ( Candida albicans ) and antimicrobial (methicillin-resistant Staphylococcus aureus ) properties have been described for extracts of the root bark.
Certificate of Analysis
|Appearence||Redish brown powder||N/A||Complies|
|Particle size||100% pass 80 mesh||USP32<786>||Complies|
|Loss on Drying||≤5.0%||Eur.Ph.6.0[2.8.17]||Complies|
|Solvents Residue||Meet Eur.Ph6.0<5.4>||Eur.Ph 6.0<2.4.24>||Complies|
|Total bacterial count||≤1000cfu/g||USP30<61>||Complies|
|Yeast & mold||≤100cfu/g||USP30<61>||Complies|
Flowchart of Production
Package for Goji Berry Extract Polysaccharide
Shipping for Goji Berry Extract Polysaccharide
- By Express: Suitable for under 50kg, 5-10 days
- By Air: Suitable for more than 50kg, 7-15 days
- By Sea: Suitable for more than 500kg, 15-45days
Why Choose FYZ Goji Berry Extract Polysaccharide?
- FYZ is a professional GMP standard herbal extract manufacturer in China, provide OEM service.
- FREE SAMPLE with freight collection (5-10g) for detection, if you need more, please contact us.
- Fast delivery by DHL/FedEx, air as your requirement.
- All of our products from nature, no additive.
- Money refund policy.